解瑞玲, 董伯升, 庞慧, 成媛, 尚可, 李醒亚. 肿瘤相关巨噬细胞在食管癌组织浸润及其对预后的影响[J]. 中国肿瘤临床, 2011, 38(2): 83-86 . DOI: 10.3969/j.issn.1000-8179.2011.02.006
引用本文: 解瑞玲, 董伯升, 庞慧, 成媛, 尚可, 李醒亚. 肿瘤相关巨噬细胞在食管癌组织浸润及其对预后的影响[J]. 中国肿瘤临床, 2011, 38(2): 83-86 . DOI: 10.3969/j.issn.1000-8179.2011.02.006
shu

肿瘤相关巨噬细胞在食管癌组织浸润及其对预后的影响

    摘要
  • 摘要: 目的：探讨肿瘤相关巨噬细胞（tumor-associated macrophages， TAMs）在食管癌组织浸润密度、分布及对预后的影响。方法：应用免疫组化方法检测CD68阳性巨噬细胞在食管癌组织及癌旁正常组织的浸润，比较癌旁正常组织和食管癌组织中巨噬细胞浸润密度，并分析癌组织中TAMs浸润密度、分布对食管癌患者生存时间及预后的影响。结果：食管癌组织TAMs浸润密度明显高于癌旁正常组织（P<0.05）。食管癌间质和癌巢TAMs浸润高密度组5年生存率低于低密度组（P<0.05）；癌间质TAMs浸润高密度组5年生存率明显低于低密度组 （P<0.05）；相反，癌巢TAMs浸润高密度组5年生存率高于低密度组 （P<0.05）。癌间质和癌巢、癌间质TAMs浸润密度与患者生存时间均呈负相关性 （P<0.05）；癌巢TAMs浸润密度与患者生存时间呈正相关（P>0.05），癌间质及癌巢TAMs浸润密度是独立的预后因素（P均<0.05）。结论：TAMs在食管癌组织中具有较高的浸润密度，且不同微环境的浸润密度不同，与患者生存时间及预后具有相关性。

     

    Abstract: Tumor-associated Macrophages in Esophageal Carcinoma and Its Impact on PrognosisRuiling XIE1, Bosheng DONG2, Hui PANG1, Yuan CHENG1, Ke SHANG1, Xingya LI1Correspondence to: Xingya LI, E-mail: zlzjonline@yahoo.com.cn1Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China2Department of Oncology, Zhoukou Central Hospital, Zhoukou 466000, ChinaAbstract Objective: To investigate the infiltration of tumor-associated macrophages (TAMs) in the tissue of esophageal carcino-ma and its impact on patient prognosis. Methods: Immunohistochemistry was used to investigate the infiltration of TAMs expressingCD68 in esophageal carcinoma tissue and adjacent normal tissue. The density of macrophage infiltration between the esophageal carci-noma and the adjacent normal tissue was compared, and the density and distribution of macrophage infiltration in the esophageal carci-noma tissue was analyzed to find its impact on patient survival. Results: The mean density of TAMs infiltrating esophageal carcinomatissue was significantly higher than that in normal adjacent tissue ( P < 0.05). Compared with patients with a low density of TAMs instroma and cancerous tissue, the patients with a high density of TAMs had a shorter five-year survival rate ( P < 0.05 ). The five-yearsurvival rate for patients with a low density of TAMs in stroma was much shorter than that for the patients who have a low density ofTAMs in the same tissue ( P < 0.05 ). The five-year survival rate was longer for the patients with a low density of TAMs in the cancernest than in patients with a high density of TAMs in the cancer nest ( P < 0.05 ). The infiltration density of TAMs in the cancer stromaand nest was negatively correlated with patient survival ( P < 0.05 ). The infiltration of TAMs in stroma and cancer nest was indepen-dent prognostic factors affecting the patient survival ( P < 0.05 ). Conclusion: There is a higher density of TAMs in esophageal carcino-ma than in normal esophageal tissue. The degree of TAM infiltration in different parts of esophageal carcinoma is correlated with pa-tient survival and prognosis.

     

    • HTML全文
    • 参考文献(0)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回